Precision Analytics – Predictive Insights
We look at what happens to a food ingredient after it is eaten: how it is absorbed, where it goes in the body, and what it does in the cells. To answer this, we combine four approaches.
1. Absorption (bioavailability). Using in-vitro simulation of digestion, we determine which food-borne molecules can pass from the gastrointestinal tract into the blood.
2. Cellular uptake and effect. On human cell cultures, we test whether these molecules enter organ cells, what they do there and how the cells respond, for example to AGEs (Advanced Glycation End-products) or oxidative stress.
3. In-silico simulation. With these data, our ADME software simulates how the ingredient is absorbed, distributed, metabolised and excreted. This gives a well-founded estimate of the likely in-vivo outcome and, in many cases, makes costly and ethically sensitive animal or human experiments unnecessary at the screening stage.
4. Human study (optional). Where needed, for example to substantiate a health claim, we confirm the results in volunteers using validated biomarkers such as F2-isoprostanes for oxidative stress. Our simulation helps define the right sampling time points and the concentrations to expect. Plus it helps to minimize the number of necessary probands. That means significant reduction of costs.
How it works: You send us your ingredient or finished product, we agree with you on the right set of tests, we carry out the studies, and you receive a written report with our results. This shows you early, before you invest in a costly clinical trial, whether your health claim is worth pursuing, and it provides supporting evidence for an EFSA dossier.
Software Prediction of Food Effects on the Human Body
Institut Kurz has developed a groundbreaking software to predict the intriguing effects of food ingredients on human cells, organs, and the entire body. Our revolutionary software integrates cellular dynamics, organ-level interactions, and systemic outcomes, providing a sophisticated understanding of how food shapes health and well-being.
Advance Science of AGEs Measurement
Formed during aging or from heat-treated foods, Advanced Glycation End-products (AGEs) are linked to diseases like cardiovascular issues, Alzheimer’s and osteoporosis. Institut Kurz has developed advanced methods to measure AGEs in food, in human tissue and in human cells. We are able to test the efficacy of your nutritional supplement or your special food ingredient with respect to suppressing or even cleaning up AGEs in the body. As innovators in AGEs analysis, we provide critical insights into their impact on health and nutrition.
Bioavailability and Effect of Ingredients
We look at active ingredients which come through the gastrointestinal tract or through the skin into the blood stream. From there they enter body cells, initiate functions within the body cells and appear as traces of the ingredients themselves or of the reaction products/metabolites again in the blood and in urine. We measure all these stages for you in vivo and we simulate each stage in vitro. Thus we provide evidence on all aspects around bioavailability and effects in vivo, in vitro, or in silico.
Cells Test
Whether a chemical substance can exert a desired (or feared) effect in the human body can be pre-clarified to a certain extent by means of experiments on cell colonies. Such preliminary experiments should be undertaken in any case before in vivo experiments are performed. We offer such preliminary experiments. Together with the metabolism simulations we also offer, this allows good predictions of the outcome of in vivo detection to be given.
ORAC and CAA Test Combo
Institut Kurz supports you in designing your food that really reduces oxidant damage to your body. Institut Kurz measures all four stages, which your food needs to pass, in order to qualify as antioxidant food: ORAC-Test: Determines, whether the food on the laboratory table has chemical antioxidant properties; Bio-availability-Test: Determines, whether the functional molecules in your food make it to the blood level after consumption; CAA-Test: Determines, whether the functional molecules of your food are able to pass from blood into the cells and whether they exhibit antioxidative effects inside the cells; Antioxidant- effect-Test: Determines by help of a bio-marker called F2-isoprostanes, whether the human body really reduces the number of oxidative attacks to its body cells. This Combo of tests gives you certainty about the antioxidative effects of your food and diet.
Preparation of Dossiers for EFSA
How Can You Prove That a Health Claim Is True?
How can you present a Novel Food to EFSA?
We prepare the relevant Dossiers for you for both questions which you can transmit to EFSA.
Institut Kurz GmbH Nattermannallee 1 · 50829. COLOGNE
+49 (0) 160 90679062
info@institut-kurz.com
info@institut-kurz.de