When it comes to nutritional effects, Institut Kurz is closing the gap between in-vivo tests and in-vitro tests plus software simulation.

How can the transport of substances in the body be simulated?

We have developed an ADME software ( Administration, Distribution, Metabolization, Excretion ) which can be calibrated with the results suitable in-vitro tests and can predict sufficiently reliably the results of in-vivo with probands or patients.

Use of software in nutritional sciences , medicine and pharmacy

ADME plus in-vitro calibration measurements can be used to identify 

           +test variations of food supplements relative to each other   with respect to their effect 

           +Predict results of in-vivo studies with sufficient precision. 

In-vivo experiments on questions that can also be clarified with sufficient reliability in-vitro/in-silico are no longer ethically justifiable.

Health effects, for which no biomarkers can be defined as endpoints, are doubtful and difficult to prove (namely only through observational studies lasting decades). 

Effects of nutritive molecules that cannot be shown on the relevant cell model are very likely to be non-existent. 

For effect hypotheses that cannot be shown individually in-vitro, no hopes for "holistic" effects should be cherished and no in-vivo experiments should be performed.

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